Tag: mRNA vaccine

Bivalent COVID-19 vaccines for general population allowed

Bivalent COVID-19 vaccines for general population allowed

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More patients around the country can avail of the bivalent vaccines for COVID-19 as a result of the Department of Health’s (DOH) revision of its guidelines, according to a Manila Times news report. This developed as less than 50% of the initial batch of bivalent vaccines have been used on patients limited to health care workers and senior citizens.

To put things in perspective, posted below is an excerpt from the Manila Times report. Some parts in boldface…

THE general population can now be administered with Covid-19 bivalent vaccine after the Department of Health (DoH) issued revised guidelines on the updated jab.

A bivalent vaccine protects against both the original virus that causes Covid-19 and the Omicron variants.

In a memorandum dated July 10 but was released to the public only this week, the DoH said those under the A3 group, meaning persons with comorbidities and compromised immunity, can now receive the Pfizer bivalent vaccine in hospitals and health facilities nationwide.

Health Secretary Teodoro Herbosa added that the general public can also avail of bivalent vaccine, noting their decision stemmed from the slow consumption of the updated jab among the A1 (health care workers) and A2 (senior citizen) subgroups. He said only 38 percent of the 391,000 donated doses allotted for these groups were used.

“Because of that, we have decided to make it available to those who want to get vaccinated with the booster. We only decided on this last week as the uptake was slow,” Herbosa said in Filipino and English in a radio interview.

The government’s stock of donated bivalent vaccines are set to expire on July 31, with an extension date of August 30.

Herbosa said a person can only receive a bivalent vaccine four to six months after getting the second booster dose.

He added that the government is negotiating with the global Covax Facility for additional bivalent vaccine doses.

Pfizer, Herbosa said, has issued a certificate of product registration that would make the vaccine available in drugstores across the country, but the lack of local cold chain storage proves to be a hindrance.

Let me end this piece by asking you readers: What is your reaction to this recent development? Are there many people in your local community who have been wanting to get immunized with the bivalent vaccines?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below, share this article to others and also please consider making a donation to support my publishing. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/ and on Instagram athttps://www.instagram.com/authorcarlocarrasco

COVID-19 Crisis: Moderna vaccination inside Alabang Hills Village set for July 16, 2022

COVID-19 Crisis: Moderna vaccination inside Alabang Hills Village set for July 16, 2022

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In a recent bulletin published through their official website, the Alabang Hills Village Association (AHVA) announced that it will be conducting a new vaccination event on July 16, 2022 using doses of COVID-19 vaccines from Moderna. There will be vaccination shots for patients taking their first dose, their second dose, their 1st booster shot (for those who got fully vaccinated already) and the 2nd booster shot (limited to senior citizens, healthcare workers and patients certified as immunocompromised).

To put things in perspective, posted below is the excerpt from the AHVA bulletin. Some parts in boldface…

Further to our last bulletin on Moderna vaccination events, Bulletin No. 2022-0608 dated June 9, 2022, we are happy to say that we will be conducting another vaccination event on the 16th of July. Zuellig has advised us that we have non-expired stocks of the vaccine in their cold storage, enabling this July 16 vaccination event to be held.

Further, given the DOH’s announcement just yesterday that second boosters can now be administered to immunocompromised children 12-17 years old, this category of individuals will also be included for inoculation on July 16.

The details of the July 16 vaccination event are as follows:

1st and 2nd Doses for General Population
1st Booster for General Population
2nd Booster for Seniors and Healthcare Workers
8:00 AM – 12:00 NN
Multi-purpose Pavilion

2nd Booster for Immunocompromised Individuals including Immunocompromised 12-17 year old children
1:00 PM – 3:00 PM
Clubhouse entrance via drive-thru

Please note that the DOH has not yet authorized 2nd booster shots for the general population below the age of 60.

Primary Dose Series (1st and 2nd Doses)
If you have not even had yet the first dose of the vaccine, please do take advantage of this July 16 schedule to get inoculated.

If you have not yet had your second dose of the vaccine, please ensure that you will have met the REQUISITE 4 WEEKS INTERVAL between your first and second doses by July 16.

First Booster
For those who would like to get their first booster shot, please ensure that you will have met the REQUISITE 3 MONTHS INTERVAL between your second dose and booster shot by July 16.

Second Booster
If you are a Senior (60 years and above), healthcare worker, or an immunocompromised individual wanting to get your second booster shot, please ensure that you will have met the REQUISITE 4 MONTHS INTERVAL between your first and second booster shots by July 16. This requirement also applies to immunocompromised individuals 12-17 years old.

Immunocompromised individuals are strictly defined by the DOH as those in or with
a. Immunodeficiency state,
b. HIV,
c. Active cancer or malignancy,
d. Transplant recipients,
e. Undergoing steroid treatment,
f. Patients with poor prognosis / bed-ridden patients, and
g. Other conditions of immunodeficiency as certified by a physician.

Immunocompromised individuals must present a current Medical Certificate to be administered a second booster shot. This is a DOH requirement.

The above bulletin stated that patients who want to be added to AHVA’s list for vaccination are to call Jenelyn Esteves or PJ Nierves at landline numbers 8850-8254, 8860-9631 or at mobile number 0906-023-2089 ASAP. Slots for vaccination are limited and the cut-off for registration is set for July 14, 2022 at 10AM.

For the newcomers reading this, the AHVA previously organized Moderna vaccination activities. Those who missed out on that should consider getting listed for the July 16 Moderna vaccination.

For further inquiries, visit https://alabanghillsvillage.com/

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/ and on Instagram at https://www.instagram.com/authorcarlocarrasco/

For more South Metro Manila community news and developments, come back here soon. Also say NO to fake news, NO to irresponsible journalism, NO to misinformation, NO to plagiarists, NO to reckless publishers and NO to sinister propaganda when it comes to news and developments. For South Metro Manila community developments, member engagements, commerce and other relevant updates, join the growing South Metro Manila Facebook group at https://www.facebook.com/groups/342183059992673

COVID-19 Crisis: Sputnik M vaccine for adolescents (aged 12 to 17) authorized for use in Kazakhstan

COVID-19 Crisis: Sputnik M vaccine for adolescents (aged 12 to 17) authorized for use in Kazakhstan

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Here in the Philippines, the vaccination of minors specifically aged 12 to 17-years-old has been going on for some time now while the vaccination of younger minors aged 5 to 11-years-old is gradually increasing. My concern is that Pfizer’s flawed COVID-19 vaccine has been used mainly on minors aged 5 to 17 (for references, click here and here) as it has been proven that the said vaccine – which uses mRNA technology – provides patients very weak protection from the infectious Omicron variant. The other vaccine used for minors aged 12-17 is Moderna which happens to also be an mRNA vaccine. The more Pfizer vaccines is used in the country, the more concerning it becomes.

Over there in Kazakhstan, it has been announced officially that Sputnik M – a COVID-19 vaccine for patients aged 12 to 17-years-old – has been authorized by the nation’s Health Ministry for use on their adolescents.

To put things in perspective, posted below is the excerpt from the official press release  published by SputnikVaccine.com Some parts in boldface…

The Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund) today announced that the Ministry of Health of the Republic of Kazakhstan has authorized the use of Sputnik M Russian vaccine for adolescents aged 12-17.

Thus Kazakhstan has become the first country outside Russia to authorize the use of Sputnik M.

In contrast with some international producers offering their vaccines in the same dosage for both adults and adolescents, the Gamaleya Center has developed Sputnik M specifically for adolescents.

Sputnik M is a two-shot vaccine based on the same human adenoviral vectors platform, which is safe and has been widely studied for over 30 years. The only difference between Sputnik M and Sputnik V is a lower concentration of viral particles per dose: Sputnik M for adolescents has 5 times less concentration in comparison with the original Sputnik V in both shots.

Russian Ministry of Health registered Sputnik M on November 24, 2021 based on data from clinical trials confirming the high safety and immunogenicity profile of Sputnik M among adolescents. During the trials there were no serious adverse events registered following vaccination with Sputnik M. Current results are corresponding with those obtained during clinical trials and real-world data on Sputnik V after vaccinating adults.

Sputnik V has been authorized in 71 country with total population of over 4 billion people. It induces stronger and longer lasting immune response against COVID (including the Omicron variant) than many other vaccines, which is further strengthened by Sputnik Light booster. A unique comparative study[1] conducted at Lazzaro Spallanzani National Institute for Infectious Diseases in Italy by a team of 12 Italian and 9 Russian scientists has shown that Sputnik V vaccine demonstrates more than 2 times higher titers of virus neutralizing antibodies to Omicron (B.1.1.529) variant than 2 doses of Pfizer vaccine (2.1 times higher in total and 2.6 times higher 3 months after vaccination).

The study was conducted in the equal laboratory conditions on comparable sera samples from individuals vaccinated with Sputnik V and Pfizer with a similar level of IgG antibodies and virus neutralizing activity (VNA) against Wuhan variant. Sputnik V showed significantly smaller (2.6 times) reduction of virus neutralizing activity against Omicron as compared to reference Wuhan variant than Pfizer vaccine (8.1-fold reduction for Sputnik V in contrast to 21.4-fold reduction for Pfizer vaccine).

It should be remembered that a study in Italy confirmed that Sputnik V provides strong resistance against the Omicron variant and that is reassuring because Sputnik M is derived from Sputnik V. If only the government here in the Philippines would make the right decision to acquire more Sputnik vaccines and immunizing as many Filipinos with them. Right now, the Omicron variant does seem to be bothering Filipinos and in recent times the daily count of new COVID-19 infections nationwide has fallen down significantly.

Let me end this piece by asking you readers: What do you think about this newest development? Are you convinced that the national government as well as local government units (LGUs) should seriously consider acquiring more doses of Sputnik V and Sputnik Light vaccines to really immunize as many Filipinos as possible as part of the effort to lift the country up from this pandemic? Don’t you feel concerned about the Pfizer vaccine’s weak protection from the Omicron variant?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  HavenorFantasy@twitter.com as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: RDIF and Gamaleya point to Italy study confirming Sputnik V vaccine provides strong protection against Omicron variant

COVID-19 Crisis: RDIF and Gamaleya point to Italy study confirming Sputnik V vaccine provides strong protection against Omicron variant

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With the whole world continues to struggle hard with COVID-19 problems as well as the highly infectious Omicron variant, a recent study conducted in Italy by the Spallanzani Institute confirmed what was determined by other studies before – Sputnik V provides strong protection against the Omicron variant. The Russian Direct Investment Fund (RDIF) and Gamaleya highlighted the newest study at the Sputnik Vaccine website very recently as well as other notable updates and detailed references.

To put things in perspective, posted below is the excerpt from the press release at SputnikVaccine.com. Some parts in boldface…

The Gamaleya National Research Center of Epidemiology and Microbiology (Gamaleya Center) and the Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund, investor in Sputnik V and Sputnik Light coronavirus vaccines), today announced a unique independent comparative study conducted at the National Institute for Infectious Diseases Lazzaro Spallanzani (Italy) by a joint team of researchers of the Institute and the Gamaleya Center showing that 2 doses of Sputnik V provide more than 2 times higher geometric mean titers (GMT) of virus neutralizing antibodies to the Omicron variant of COVID than 2 doses of Pfizer vaccine (2.1 times higher in total and 2.6 times higher 3 months after vaccination).

An article by a team of 12 Italian and 9 Russian scientists led by Francesco Vaia, Director of the Spallanzani Institute and Alexander Gintsburg, Director of the Gamaleya Center, has been published in medRxiv (the preprint server for health sciences) and is available at:

https://www.medrxiv.org/content/10.1101/2022.01.15.22269335v1 

The study was conducted in Spallanzani Institute in the equal laboratory conditions at the Italian Spallanzani Institute on comparable groups of sera from individuals vaccinated with Sputnik V and Pfizer, with no statistically significant difference in neutralizing activity against Wuhan variant.The advantages of Sputnik V are the use of native S glycoprotein (spike protein without proline-stabilization and other modifications) and the use of a heterologous prime-boost vaccination regimen. The Pfizer vaccine utilizes the spike protein in a proline-stabilized form in contrast to Sputnik V. Proline-stabilization and other modifications may move an immune response predominantly to the actively mutating receptor-binding domain (RBD) of spike protein. In the Omicron variant, a substantial number of mutations were registered precisely in RBD, which is why such a significant drop in neutralizing activity against this variant may be observed in the sera of Pfizer-vaccinated.

Boosting with Sputnik Light as part of the “mix & match” approach may help address the lower efficacy of mRNA vaccines against Omicron as well as the documented, quickly waning, efficacy of mRNA vaccines against COVID-19. Partnerships between adenoviral and mRNA vaccines could provide for stronger protection against Omicron and other variants.

Based on the data collected by the Spallanzani Institute and results of previous studies, heterologous (“mix & match”) boosting with Sputnik Light is the best solution to increase other vaccines’ efficacy and extend the booster protection period as optimal adenoviral platform configuration provides better protection against Omicron and other mutations:

a. Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron, which is comparable to titers observed after Sputnik V against wild-type virus, associated with high levels of protection. The study results were summarized in an article available at:

www.medrxiv.org/content/10.1101/2021.12.17.21267976v1

b. Sputnik Light has already shown strong results as a booster in “mix & match” trials in Argentina. A combination of Sputnik Light with vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino, conducted in 5 provinces (City and Province of Buenos Aires, as well as Córdoba, La Rioja and San Luis) has demonstrated that Sputnik Light induces stronger antibody and T-cell response as compared to a homologous regimen (two shots of the same vaccine). Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on the 14th day after administering a second dose when compared to original homologous (same vaccine as first and second dose) regimens of each of the vaccines.

c. As duration of vaccine protection is key to avoid frequent boosting, authors of another study in Argentina have noted that protection against coronavirus remains stable following vaccination with the Russian Sputnik V vaccine as a consequence of antibody maturation, resulting in improved potency of antibodies to viral escape mutations:

https://www.medrxiv.org/content/10.1101/2021.08.22.21262186v1

d. The study conducted by a number of highly respected institutes in the US (Beth Israel Deaconess Medical Center, Harvard University, Ragon Institute of MGH, MIT and University of North Carolina) demonstrated that boosting Pfizer vaсcine with Ad26 vector produces optimal durable protection against Omicron with 4 times higher increase in Omicron-specific T-cells and 2.4 times in neutralizing antibody titers vs Pfizer booster. Sputnik Light is based on Ad26 vector and is the universal booster for other vaccines vs all mutations:

https://www.medrxiv.org/content/10.1101/2021.12.02.21267198v2

e. US study on 168 mln people showed that one-shot COVID vaccine based on Ad26 is superior against infections and hospitalizations to quickly waning two-shot mRNA vaccines. In the 6th month after vaccination, Pfizer protection against hospitalization waned 4 times, while there was no evidence of waning protection against hospitalization for Ad26 vector:

https://www.medrxiv.org/content/10.1101/2022.01.05.22268648v1

f. Another study conducted on almost 500,000 health care workers in South Africa demonstrated 85% efficacy of Ad26 booster against hospitalization caused by Omicron variant:

https://www.medrxiv.org/content/10.1101/2021.12.28.21268436v1.full-text

Partnership among vaccine manufacturers through heterologous (“mix & match”) boosting by other vaccines is needed to address the quickly waning efficacy of mRNA vaccines against COVID-19, which was documented in multiple studies:

a. The study in US among 65+ years old population demonstrated the decrease in mRNA vaccine effectiveness against Delta accelerated after month 4, reaching a low of approximately 20% in months 5 through 7:

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787183

b. According to Swedish data, the Pfizer vaccine’s efficacy against Delta strain is falling to below 30% after 6 months:

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3949410

c. The UK Health Security Agency said those who had received three doses of Pfizer’s vaccine saw their protection against symptomatic illness caused by Omicron variant drop to 45% within 10 weeks:

https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-technical-briefings

Alexander Gintsburg, Director of the National Research Center for Epidemiology and Microbiology, said:

“The joint study by the Gamaleya Center and Spallanzani Institute confirmed the results obtained in our separate study published in December 2021. The hard scientific data proves Sputnik V has higher virus neutralizing activity against Omicron as compared to other vaccines and will play a major role in the global fight against this new contagious variant.”

Denis Logunov, Deputy Director of the National Research Center for Epidemiology and Microbiology, noted:

“The Spallanzani Institute is one of the leading European research centers and our joint study provided a unique opportunity for independent analysis of different vaccine platforms against Omicron. Adenoviral vector platform in the core of Sputnik V and Sputnik Light vaccines once again proved to be the best solution in creating strong and durable immunity against COVID and its new variants.”

That was a huge load of information above. While the excerpt is long, I urge you all to read still read the full press release online which itself has some visual presentation of statistics and studies. For insight, read my previous Sputnik-Omicron article. As for my native Philippines, I hope that the government officials have been paying close attention to these press releases and other global studies related to Sputnik vaccines. I also hope the national authorities will acquire a lot more Sputnik vaccines to really protect Filipinos from the Omicron variant which itself caused the deaths of two people here.

Let me end this piece by asking you readers: If you have been vaccinated with a Sputnik V vaccine or the one-shot Sputnik Light vaccine, does this latest, highly detailed press release make you confident with what you have been injected with? If you have been vaccinated with Pfizer’s COVID-19 vaccine, are you convinced that the mRNA technology is flawed with regards to providing you protection against the coronvirus and its variants? 

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Metro Manila under Alert Level 2 until December 31, 2021

COVID-19 Crisis: Metro Manila under Alert Level 2 until December 31, 2021

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Good news for people of Metro Manila who are enjoying more liberty to visit friends and families, enjoying shopping and dining, and traveling more! The Alert Level 2 status for Metro Manila, which has been going on for some time now, will remain until December 31, 2021, according to a report published by the Philippine News Agency (PNA).

To put things in perspective, posted below is an excerpt from the PNA report. Some parts in boldface…

The Covid-19 Alert Level 2 status in Metro Manila will remain for the rest of the year despite the detection of a third Omicron variant case in the country, National Task Force (NTF) Against Covid-19 chief, Secretary Carlito Galvez Jr., said Monday.

The vaccine czar said the possible amendment on the alert level status will be based on the epidemiological recommendations of the Department of Health, considering key factors on cases surge and hospitalization rate.

“If the cases are high, including critical cases, and if the attack rate will increase, that’s the time we will raise our alert level,” Galvez said during a media briefing at a mall vaccination site in Taytay, Rizal.

Galvez said there is a continuing decline in Covid-19 cases in the country, with just 9,592 active infections as of Monday.

“Thank God, we maintained the low positivity rate. Actually, there are some areas that recorded less than one percent of positivity rate,” he added.

Still, he cautioned the public against complacency amid the downtrend.

“For now, we will just maintain the alert level, but we will massively accelerate the vaccination. At the same time, we will revisit our preparations in terms of treatment, quarantine facilities, and hospital treatments as well as the responses of the local government units (LGUs),” he said.

Stringent border control measures against the Omicron variant are also in place, added Galvez.

“Though we prepared a good response in terms of stringent border controls, as I’ve said earlier, we expected that,” he said. “The low cases and figures were sustained despite the opening of our economy.”

Galvez thanked anew LGUs and the private sector for proactively participating in the national Covid-19 vaccination days.

“And we have already reached our milestone of hitting 100 million jabs administered nationwide and we are now reaching 40 percent fully vaccinated out of our total population. That’s a huge milestone,” he said.

Secretary Vince Dizon, the Presidential Adviser on Covid-19 Response and NTF deputy chief, said the decision to impose lockdowns or to raise the alert level status should be based on the set parameters of number of cases, attack rate, and the two-week growth rate.

For some people, the move to retain the Alert Level 2 status for Metro Manila is surprising due to the global hardship caused by the Omicron variant (including becoming the dominant strain in the United States) which is already here in the Philippines. Still there is the fact that the daily count of new COVID-19 infections remains in the few hundreds and so far, the Omicron variant has not created a spike of new cases which is good because the Philippines is now at a stage of economic and social recovery after many months of restrictions. By the way, if you were injected with the Pfizer vaccine and are wondering how protected you are from Omicron, better read my recent article by clicking here. For those who got vaccinated with Sputnik V or Sputnik Light, click here and here.

Let me end this piece by asking you readers: What do you think about this latest development? Does the constant reporting of Omicron-related news make you feel uncomfortable? Do you believe the Alert Level 2 status extension for Metro Manila is the right move knowing that there are a few cases of Omicron here in the Philippines?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

For more South Metro Manila community news and developments, come back here soon. Also say NO to fake news, NO to irresponsible journalism, NO to misinformation, NO to plagiarists, NO to reckless publishers and NO to sinister propaganda when it comes to news and developments. For South Metro Manila community developments, member engagements, commerce and other relevant updates, join the growing South Metro Manila Facebook group at https://www.facebook.com/groups/342183059992673

COVID-19 Crisis: Gamaleya Center’s preliminary study shows Sputnik vaccines are effective against Omicron variant

COVID-19 Crisis: Gamaleya Center’s preliminary study shows Sputnik vaccines are effective against Omicron variant

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Have you been inoculated with the vaccine of Sputnik V or Sputnik Light before? In case you missed the news, the people behind the Russian vaccines made some profound announcements in relation to the Omicron variant which continues to infect a lot of people in many parts of the world (note: a 3rd Omicron case has just been confirmed here in the Philippines). Also revealed were comparisons with other brands of COVID-19 vaccines.

To put things in perspective, posted below is the first of two excerpts from the official press release published on the Sputnik Vaccine website. Some parts in boldface…

Moscow, December 17, 2021 – A preliminary laboratory study conducted by the Gamaleya Center has demonstrated that the Sputnik V vaccine and the one-shot Sputnik Light booster (based on human adenovirus serotype 26, the first component of Sputnik V) are effective against Omicron (B.1.1.529) variant of COVID, providing for better protection when compared to other vaccines.

Heterologous boosting with Sputnik Light is the solution to increase other vaccines’ efficacy, including against Omicron, and extend the booster protection period.

Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination and is a universal booster to other vaccines inducing stronger antibody and T-cell response.

Efficacy of mRNA vaccines has proven to be waning, demonstrated by a number of scientific publications. A Swedish study in The Lancet journal [4] has shown that Pfizer vaccine’s efficacy against Delta is falling to 47% after 4 months, to 29% after 6 months and to 23% after 7 months. The recent study in US among 65+ years olds demonstrated the decrease in mRNA vaccine effectiveness accelerating against Delta after month 4, reaching a low of approximately 20% in months 5 through 7 [5].

Recognizing the waning efficacy of mRNA vaccines, EU, UK, Greece, South Korea and other countries have recommended reducing the boosting period from 6 to 3 months.

Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light as well as heterologous boosting can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge.

Sputnik Light has already been registered in more than 20 countries as a standalone vaccine and a universal booster to other vaccines helping to increase their efficacy (including in Argentina, UAE, Bahrain, Philippines, and San Marino). Sputnik V has been authorized in 71 countries with total population of over 4 billion people.

Sputnik Light has already shown strong results used as a booster in mix & match trials in Argentina. A combination of Sputnik Light with vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino, conducted in 5 provinces (City and Province of Buenos Aires, as well as Córdoba, La Rioja and San Luis) has demonstrated that Sputnik Light induces stronger antibody and T-cell response as compared to homologous regimen (two shots of the same vaccine). Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on the 14th day after administering a second dose when compared to original homogenous (same vaccine as first and second dose) regimens of each of the vaccines.

Authors of a study in Argentina have noted that protection against coronavirus remains stable over at least 4 months following vaccination with the Russian Sputnik V vaccine as a consequence of antibody maturation, resulting in improved potency of antibodies to viral escape mutations. The study results were summarized in an article at https://www.medrxiv.org/content/10.1101/2021.08.22.21262186v1

Sputnik Light efficacy data:

  • Sputnik Light has been proven to be safe and highly effective by real-world vaccination data. In particular, data from the Ministry of Health of Buenos Aires (Argentina) has demonstrated standalone efficacy of Sputnik Light between 78.6-83.7% among the elderly (over 40,000 people of 60-79 years old), which is higher than that of many two-dose vaccines.
  • Findings by the Gamaleya Center based on data collected in Moscow have demonstrated Sputnik Light vaccine administered standalone has 70% efficacy against infection from the Delta variant of coronavirus during the first three months after vaccination. The vaccine is 75% effective among subjects under the age of 60. Sputnik V and Sputnik Light are based on a safe and effective human adenoviral vector platform and have not been associated with rare serious adverse events following vaccination, such as myocarditis or pericarditis.

Take note that this is not the first time that the group behind Sputnik V and Sputnik Light claimed their current vaccines are effective against the Omicron variant. Regardless, they went ahead developing a new and upcoming version of the Sputnik vaccine with Omicron in mind.

Going back to the above press release excerpt, the findings (conducted by other studies done by different research groups) exposed the weakness of mRNA vaccines particularly on efficacy against the Delta variant. If mRNA vaccines really cannot protect the vaccinated people from the Delta variant, how can they protect them from the much more contagious Omicron variant?

And now for the other details from the Sputnik Vaccine press release posted in the other excerpt below. Some parts are in bold face. Please read closely…

  • The Gamaleya Center’s recent preliminary laboratory study shows that Sputnik V demonstrates high virus neutralizing activity (VNA) against the Omicron (B.1.1.529) variant and is expected to provide strong defense against severe disease and hospitalization.
  • Sputnik V has demonstrated 3-7x less of a reduction in virus neutralizing activity against Omicron as compared to data from other vaccine producers: 11.8 times decrease of VNA for Sputnik V in contrast with 41 times decrease for Pfizer-BioNTech (according to the study led by scientists from Africa Health Research Institute published on Dec 7, 2021 [1]) and 49-84 times decrease for Moderna (according to the study published by research group from scientific institutes including Vaccine Research Center on Dec 15, 2021 [2]). So far, Sputnik V is showing the best virus neutralization results against Omicron in comparison with other vaccines.
  • The study was conducted using sera with a longer period after vaccination (more than 6 months after vaccination) as an indicator of Sputnik V’s long-lasing protection, in contrast with short studied periods for other vaccines producers (12-27 days for Pfizer-BioNTech and 28 days for Moderna).
  • Sputnik V elicits strong and long-lasting T-cell response, and as 80% of epitopes in the spike protein are not affected by the mutations in the Omicron variant, Sputnik V is expected to provide long-lasting protection against severe disease by Omicron. Sputnik V’s long-lasting T-cell immunity contributes to 80% efficacy against Delta on months 6-8 compared with efficacy of less than 29% demonstrated by certain mRNA vaccines after 6 months.
  • Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination. Virus neutralizing activity against Omicron 2-3 months after a Sputnik Light booster in this preliminary laboratory study is higher than VNA against the wild-type virus 6 months after Sputnik V vaccination. Based on these data the expected efficacy of Sputnik V with Sputnik Light booster against Omicron infection could be more than 80%, as Sputnik V showed efficacy of more than 80% against wild-type virus 6 month after vaccination.
  • 100% of individuals revaccinated with Sputnik Light as a booster developed neutralizing antibodies against Omicron and demonstrated their high level 2-3 months after the revaccination in contrast with only 25% of Pfizer booster recipients showing detectable level of neutralizing antibodies 3 month after vaccination (as demonstrated in the study published by research group from scientific institutes including Institute for Medical Virology (Frankfurt) on Dec 13, 2021 [3]).
  • Sputnik Light booster is expected to provide strong protection against infection, severe disease and hospitalization by Omicron. Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge. Sputnik Light is a universal booster to other vaccines, including Sputnik V. In Argentina, a combination of Sputnik Light with other vaccines has demonstrated its effectiveness as a universal booster inducing stronger antibody and T-cell response compared to a two-shots homologous regimen.
  • Sputnik V and Sputnik Light were developed on the basis of a safe and well-studied over 30 years technology and have not been associated with rare serious side effects as myocarditis or pericarditis.
    • The highest safety and efficacy of Sputnik V and Sputnik Light was demonstrated in more than 30 studies and real-world data publications from more than 10 countries.

Let me end this piece by asking you readers: What can you say about this latest announcement by the team behind the Sputnik vaccines? Do all the above details convince you to get a Sputnik vaccine as your first dose or as your booster shot? Has the Omicron variant infected people there in your local community?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Sputnik vaccines versus Omicron

COVID-19 Crisis: Sputnik vaccines versus Omicron

carlocarrasco

Have you been injected with a Sputnik vaccine? Are all the rabid news reports about the Omicron variant making you feel uncomfortable? Here is something that you should focus on temporarily – an official statement was recently released claiming that Sputnik V and Sputnik Light vaccines are effective against all variants of SRAC-Cov-2 and they will prove effective in neutralizing the Omicron variant. As if that was not enough, a new version of the Sputnik vaccine is already being developed with Omicron in mind.

To put things in perspective, posted below is an excerpt from the statement published by SputnikVaccine.com. Some parts in boldface…

The Russian Sputnik V and Sputnik Light vaccines have proven to be highly effective against all variants of SARC-Cov-2 known to date. This has been demonstrated by an article published in Vaccines medical journal and international real-world data from numerous countries:

A recent study in Hungary demonstrated Sputnik V vaccine had the highest (98%) efficacy in preventing COVID-related mortality and 85.7% efficacy against coronavirus infection among five vaccines (Sputnik V, Moderna, Pfizer, AstraZeneca and Sinopharm) used in the country between January-June 2021. Based on this data, the share of deaths from COVID in the unvaccinated population was 130 times higher than among those vaccinated with Sputnik V in the same period.

According to data from San Marino, Sputnik V is 80% effective against coronavirus infection from 6th to 8th months after administering the second dose, which is much higher than published efficacy of mRNA vaccines of less than 30% after 6 months.

The Sputnik vaccine’s efficacy is based on the heterogeneous boosting approach using two different vectors for two shots, pioneered by the Gamaleya Institute, and a proven adenoviral vector platform, which triggers a broader immune response as compared to mRNA vaccines.

The Gamaleya Institute believes both Sputnik V and Sputnik Light will neutralize the latest Omicron variant and has started the necessary studies.

Nonetheless the Gamaleya Institute, based on existing protocols of immediately developing vaccine versions for variants of concern, has already begun developing the new version of Sputnik vaccine adapted to Omicron. In an unlikely case such modification is needed, the new Sputnik Omicron version can be ready for mass-scale production in 45 days. Several hundred million Sputnik Omicron boosters can be provided to international markets already by Feb 20, 2022 with over 3 billion doses available in 2022.

That was a pretty bold statement there. Sputnik vaccines’ efficacies (preventing COVID-19  mortality and going against coronavirus infections) was compared with four other established brands of COVID-19 vaccines.

With regards to Omicron, there was confidence expressed that the two existing Sputnik vaccines will neutralize the new variant. That sounds great but I would love to see first real test results to prove that. Regardless, Gamaleya proceeded already to develop a newer version of Sputnik vaccine with Omicron in mind and they seem confident they can mass produce it and start releasing it in early 2022. As seen in the above statement, the mass production and release of a Sputnik Omicron vaccine would commence in the unlikely case they need to modify the Sputnik vaccine.

If the current Sputnik vaccines prove to be capable of neutralizing the Omicron variant, then no such production-release scheme of a modified vaccine will be needed. Gamaleya will then have to keep mass producing and sending out doses of Sputnik V and Sputnik Light worldwide. Already millions of doses of Sputnik V have arrived here in the Philippines and the national government plans to procure more of the single-dose Sputnik Light vaccine.

For added insight, watch these related news videos below…

Let me end this piece by asking you readers: What can you say about this official statement about Sputnik vaccines and the Omicron variant? If you were fully vaccinated with the Sputnik V vaccine, how long has it been since your 2nd dose? Is your local government already releasing booster shots? Are you eager to find out if your local government will use Sputnik vaccine as your booster shot? Do you believe that Gamaleya’s statement that the two current Sputnik vaccines will really neutralize the Omicron variant?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

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