COVID-19 Crisis: RDIF and Gamaleya point to Italy study confirming Sputnik V vaccine provides strong protection against Omicron variant

With the whole world continues to struggle hard with COVID-19 problems as well as the highly infectious Omicron variant, a recent study conducted in Italy by the Spallanzani Institute confirmed what was determined by other studies before – Sputnik V provides strong protection against the Omicron variant. The Russian Direct Investment Fund (RDIF) and Gamaleya highlighted the newest study at the Sputnik Vaccine website very recently as well as other notable updates and detailed references.

To put things in perspective, posted below is the excerpt from the press release at SputnikVaccine.com. Some parts in boldface…

The Gamaleya National Research Center of Epidemiology and Microbiology (Gamaleya Center) and the Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund, investor in Sputnik V and Sputnik Light coronavirus vaccines), today announced a unique independent comparative study conducted at the National Institute for Infectious Diseases Lazzaro Spallanzani (Italy) by a joint team of researchers of the Institute and the Gamaleya Center showing that 2 doses of Sputnik V provide more than 2 times higher geometric mean titers (GMT) of virus neutralizing antibodies to the Omicron variant of COVID than 2 doses of Pfizer vaccine (2.1 times higher in total and 2.6 times higher 3 months after vaccination).

An article by a team of 12 Italian and 9 Russian scientists led by Francesco Vaia, Director of the Spallanzani Institute and Alexander Gintsburg, Director of the Gamaleya Center, has been published in medRxiv (the preprint server for health sciences) and is available at:

https://www.medrxiv.org/content/10.1101/2022.01.15.22269335v1 

The study was conducted in Spallanzani Institute in the equal laboratory conditions at the Italian Spallanzani Institute on comparable groups of sera from individuals vaccinated with Sputnik V and Pfizer, with no statistically significant difference in neutralizing activity against Wuhan variant.The advantages of Sputnik V are the use of native S glycoprotein (spike protein without proline-stabilization and other modifications) and the use of a heterologous prime-boost vaccination regimen. The Pfizer vaccine utilizes the spike protein in a proline-stabilized form in contrast to Sputnik V. Proline-stabilization and other modifications may move an immune response predominantly to the actively mutating receptor-binding domain (RBD) of spike protein. In the Omicron variant, a substantial number of mutations were registered precisely in RBD, which is why such a significant drop in neutralizing activity against this variant may be observed in the sera of Pfizer-vaccinated.

Boosting with Sputnik Light as part of the “mix & match” approach may help address the lower efficacy of mRNA vaccines against Omicron as well as the documented, quickly waning, efficacy of mRNA vaccines against COVID-19. Partnerships between adenoviral and mRNA vaccines could provide for stronger protection against Omicron and other variants.

Based on the data collected by the Spallanzani Institute and results of previous studies, heterologous (“mix & match”) boosting with Sputnik Light is the best solution to increase other vaccines’ efficacy and extend the booster protection period as optimal adenoviral platform configuration provides better protection against Omicron and other mutations:

a. Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron, which is comparable to titers observed after Sputnik V against wild-type virus, associated with high levels of protection. The study results were summarized in an article available at:

www.medrxiv.org/content/10.1101/2021.12.17.21267976v1

b. Sputnik Light has already shown strong results as a booster in “mix & match” trials in Argentina. A combination of Sputnik Light with vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino, conducted in 5 provinces (City and Province of Buenos Aires, as well as Córdoba, La Rioja and San Luis) has demonstrated that Sputnik Light induces stronger antibody and T-cell response as compared to a homologous regimen (two shots of the same vaccine). Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on the 14th day after administering a second dose when compared to original homologous (same vaccine as first and second dose) regimens of each of the vaccines.

c. As duration of vaccine protection is key to avoid frequent boosting, authors of another study in Argentina have noted that protection against coronavirus remains stable following vaccination with the Russian Sputnik V vaccine as a consequence of antibody maturation, resulting in improved potency of antibodies to viral escape mutations:

https://www.medrxiv.org/content/10.1101/2021.08.22.21262186v1

d. The study conducted by a number of highly respected institutes in the US (Beth Israel Deaconess Medical Center, Harvard University, Ragon Institute of MGH, MIT and University of North Carolina) demonstrated that boosting Pfizer vaсcine with Ad26 vector produces optimal durable protection against Omicron with 4 times higher increase in Omicron-specific T-cells and 2.4 times in neutralizing antibody titers vs Pfizer booster. Sputnik Light is based on Ad26 vector and is the universal booster for other vaccines vs all mutations:

https://www.medrxiv.org/content/10.1101/2021.12.02.21267198v2

e. US study on 168 mln people showed that one-shot COVID vaccine based on Ad26 is superior against infections and hospitalizations to quickly waning two-shot mRNA vaccines. In the 6th month after vaccination, Pfizer protection against hospitalization waned 4 times, while there was no evidence of waning protection against hospitalization for Ad26 vector:

https://www.medrxiv.org/content/10.1101/2022.01.05.22268648v1

f. Another study conducted on almost 500,000 health care workers in South Africa demonstrated 85% efficacy of Ad26 booster against hospitalization caused by Omicron variant:

https://www.medrxiv.org/content/10.1101/2021.12.28.21268436v1.full-text

Partnership among vaccine manufacturers through heterologous (“mix & match”) boosting by other vaccines is needed to address the quickly waning efficacy of mRNA vaccines against COVID-19, which was documented in multiple studies:

a. The study in US among 65+ years old population demonstrated the decrease in mRNA vaccine effectiveness against Delta accelerated after month 4, reaching a low of approximately 20% in months 5 through 7:

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2787183

b. According to Swedish data, the Pfizer vaccine’s efficacy against Delta strain is falling to below 30% after 6 months:

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3949410

c. The UK Health Security Agency said those who had received three doses of Pfizer’s vaccine saw their protection against symptomatic illness caused by Omicron variant drop to 45% within 10 weeks:

https://www.gov.uk/government/publications/investigation-of-sars-cov-2-variants-technical-briefings

Alexander Gintsburg, Director of the National Research Center for Epidemiology and Microbiology, said:

“The joint study by the Gamaleya Center and Spallanzani Institute confirmed the results obtained in our separate study published in December 2021. The hard scientific data proves Sputnik V has higher virus neutralizing activity against Omicron as compared to other vaccines and will play a major role in the global fight against this new contagious variant.”

Denis Logunov, Deputy Director of the National Research Center for Epidemiology and Microbiology, noted:

“The Spallanzani Institute is one of the leading European research centers and our joint study provided a unique opportunity for independent analysis of different vaccine platforms against Omicron. Adenoviral vector platform in the core of Sputnik V and Sputnik Light vaccines once again proved to be the best solution in creating strong and durable immunity against COVID and its new variants.”

That was a huge load of information above. While the excerpt is long, I urge you all to read still read the full press release online which itself has some visual presentation of statistics and studies. For insight, read my previous Sputnik-Omicron article. As for my native Philippines, I hope that the government officials have been paying close attention to these press releases and other global studies related to Sputnik vaccines. I also hope the national authorities will acquire a lot more Sputnik vaccines to really protect Filipinos from the Omicron variant which itself caused the deaths of two people here.

Let me end this piece by asking you readers: If you have been vaccinated with a Sputnik V vaccine or the one-shot Sputnik Light vaccine, does this latest, highly detailed press release make you confident with what you have been injected with? If you have been vaccinated with Pfizer’s COVID-19 vaccine, are you convinced that the mRNA technology is flawed with regards to providing you protection against the coronvirus and its variants? 

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

+++++

Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Around 100 million vaccine doses in stock for the entire Philippines according to Galvez

Recently vaccine czar Carlito Galvez, Jr., stated that the Philippines has more or less one hundred million doses of COVID-19 vaccines in stock, according to a Manila Bulletin news report. What is clearly lacking, however, is the specific brands for the current vaccine stockpile.

To put things in perspective, posted below is the excerpt from the Manila Bulletin report. Some parts in boldface…

More or less 100 million doses of vaccines against the coronavirus disease (COVID-19) are still in the government’s stockpile and will be used to vaccinate some 28 million to 30 million Filipinos who remain unvaccinated.

Sec. Carlito Galvez, Jr., vaccine czar and chief implementer of the National Task Force Against COVID-19, said the remaining doses are also enough for the booster shots of 25 million Filipinos.

“Mayroon po tayong babakunahan pa na primary series o ‘yung unang bakuna sa 28-30 million na katao (We have 28 to 30 million people who are on our primary list or those who are yet to receive the vaccines,” said Galvez.

“Though ‘yung 100 million doses na nasa stockpile po natin ay sapat sa remaining primary series ng unvaccinated at para sa 25 million na eligible ngayong quarter for boosters (The 100 million doses in our stockpile are enough for the remaining primary series of unvaccinated and for the 25 million who are eligible for booster this (first) quarter),” he added.

As of January 10, a total of 114,263,805 vaccine doses have been administered nationwide. Of this number, 52,856,932 individuals are already fully vaccinated.

The vaccination and booster shots that are being eyed to be completed with the first quarter of this year (January to March) is part of the first milestone of the NTF Against COVID-19.

Galvez said they are also eyeing the completion of its target of vaccinating 90 million by the end of the second quarter.

As seen in the above article, there was no breakdown as to what brands of vaccines are part of the current national supply. As it is believed that the Omicron variant is the cause behind the current COVID-19 surge around the country, the national authorities as well as the local government units (LGUs) should seriously consider acquiring a lot more Sputnik vaccines (for more on Sputnik vaccines effectiveness against Omicron variant, click here and here) to really help entire nation. It’s high time for the Philippines to negotiate with their Russian counterparts for more Sputnik vaccines. Take note that the nation of Tunisia approved the use of the single-dose Sputnik Light vaccine as their universal booster.

Let me end this piece by asking you readers: Do you think that the current supply of COVID-19 vaccines for the entire Philippines will be fully used by the end of June 2022? Are you very conscious about what brands of vaccines the government keeps on ordering and receiving? Are there people in your local community who remain unvaccinated because of phobia towards vaccines or needles?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

+++++

Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Philippines should have more Sputnik vaccines to combat Omicron variant

While it is nice to know that my native Philippines has secured over two hundred million doses of COVID-19 vaccines and the vaccination operations around the country include the issuance of booster shots, I honestly believe that more Sputnik vaccines (Sputnik V, Sputnik Light and the upcoming new Sputnik vaccine designed with Omicron in mind) are needed in the country and more of them should be secured especially since the Omicron variant is infecting more people locally.

In 2021, the Philippines received millions of Sputnik V vaccines but too little of the single-dose Sputnik Light. Good thing that the Philippines will negotiate for more Sputnik Light vaccines because in recent news, Sputnik Light has been approved in Tunisia as a universal booster!

To put things in perspective, posted below is the excerpt from the SputnikVaccine.com press release. Some parts in boldface…

Moscow, December 29, 2021 – The Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund) announces the approval of the Russian one-shot Sputnik Light vaccine against coronavirus as a universal booster shot by Tunisia’s Ministry of Health.

Sputnik Light is based on recombinant human adenovirus serotype number 26 (the first component of Sputnik V). A one-shot vaccination regimen of Sputnik Light provides for ease of administration and helps to increase efficacy and duration of other vaccines when used as a booster shot. Sputnik Light has already been authorized in more than 30 countries.

Clinical studies and the real-world data in many countries have demonstrated that Sputnik Light is a safe and effective vaccine when used both on a standalone basis and as a booster.

A study in Argentina on heterogeneous regimens combining Sputnik Light and vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino has demonstrated that Sputnik Light is an effective universal booster. Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on 14th day after administering the second dose as compared to original homogenous (same vaccine as first and second dose) regimens of each of the vaccines.

A preliminary study of the Gamaleya Center has found Sputnik Light significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination with 100% of individuals revaccinated with Sputnik Light as a booster having developed neutralizing antibodies against this variant. Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge.

Sputnik Light efficacy data:

  • Sputnik Light has been proven to be safe and highly effective by real-world vaccination data. In particular, data from the Ministry of Health of Buenos Aires (Argentina) has demonstrated standalone efficacy of Sputnik Light between 78.6-83.7% among the elderly (over 40,000 people of 60-79 years old), which is higher than that of many two-dose vaccines.
  • Findings by the Gamaleya Center based on data collected in Moscow have demonstrated Sputnik Light vaccine administered standalone has 70% efficacy against infection from the Delta variant of coronavirus during the first three months after vaccination. The vaccine is 75% effective among subjects under the age of 60. Sputnik V and Sputnik Light are based on a safe and effective human adenoviral vector platform and have not been associated with rare serious adverse events following vaccination, such as myocarditis or pericarditis.

Previously, it has been declared that Sputnik V and Sputnik Light are highly effective against the Omicron variant (referencing an article published in Vaccines medical journal and international real-world data from numerous countries) and Gamaleya itself conducted a preliminary study confirming the findings.

As for the Omicron variant situation here in the Philippines, Sputnik vaccines would be more crucial for public health especially since there are many Filipinos who have been vaccinated with the Sinovac vaccine which according to a recent study was found to be weaker versus Omicron. Once the Sinovac protection has faded away, there is the potential of a wave of new COVID-19 infections caused by the Omicron variant. Right now, we can only hope that the Philippines is negotiating with their counterparts in Russia to acquire many millions of new doses of Sputnik V, Sputnik Light and the upcoming new Sputnik (designed with Omicron in mind).

Let me end this piece by asking you readers: Have you been vaccinated previously with Sputnik V or Sputnik Light? If you were fully vaccinated with Sinovac, do you prefer a Sputnik vaccine to be your booster shot?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

+++++

Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Slight rise in Metro Manila’s COVID-19 positivity rate was due to holiday frenzy according to OCTA Research

As far as Metro Manila goes, the slight increase of the COVID-19 positivity rate was caused not by the media-magnified Omicron variant but by the holiday frenzy according to OCTA Research in an article published by the Philippine News Agency (PNA).

To put things in perspective, posted below is the excerpt from the PNA report. Some parts in boldface…

The slight increase in Metro Manila’s Covid-19 positivity rate, average daily attack rate (ADAR), and reproduction rate was due to the holiday frenzy and not necessarily because of the Omicron variant, OCTA Research fellow Dr. Guido David said on Monday.

David said it is premature to say that the newest coronavirus variant had something to do with the spike in numbers.

Based on two-week growth rates (TWGR), David reported that the current reproduction number is at 0.85 percent while the ADAR in the National Capital Region (NCR) is at 0.82 percent.

The positivity rate slightly increased to 1.4 percent.

“So, hindi natin masasabi ngayon na Omicron-driven ito dahil nakita rin naman natin ito last year. Siguro doon sa pagtitipun-tipon ng mga kababayan natin kaya kailangan doble pag-iingat lang naman din ang kinakailangan natin (So we can’t really say that it is Omicron-driven because we have seen this last year. The gatherings might have caused this, so we just really need to be extra careful),” he said in a media briefing.

As of Monday, the country has 9,579 active Covid-19 cases, the 10th straight day that the tally was below 10,000.

Four cases of the Omicron variant have been confirmed so far.

Just like last year, David noted that the Covid-19 testing slowed down as laboratories took a break and the recent onslaught of Typhoon Odette affected the operations of some testing centers.

He said a “clear picture” as to how the Covid-19 cases suddenly increased might be available until the first week of January next year.

“Ang nangyari naman noong January this year lang, noong January of 2021, iyong uptick ay bumalik na siya sa normal level. So bumaba ulit siya. Iyon iyong sanang gusto nating makita ngayon na after January, kapag na-resolve na iyong testing, iyong kakulangan natin sa testing at iyong mga closed laboratories ay bababa ulit sa normal levels ang bilang ng kaso. Iyan iyong gusto nating mangyari (So, in January this year, the uptick went back to its normal level. So it went down again. So, that’s what we want to see after January [next year], if we resolved our backlogs in testing and in our laboratories, then the cases will go back to normal levels. That’s what we want to happen),” David said.

David sees no need yet to increase restrictions or push for premature interventions.

“It could just be a holiday uptick, which means na after the holidays, possibly bababa din iyong number of cases and iyong positivity rate (it is possible that the number of cases and the positivity rate will go down),” he added.

As I personally observed, a lot of people and families have been moving around not only because of the Alert Level 2 status of Metro Manila but also because of Christmas-related activities like shopping, touring and dining inside restaurants. I myself saw lots of people moving inside and around Festival Mall and the Alabang Town Center here in Muntinlupa City in the days leading to Christmas. Also there were families who had Christmas parties or small gatherings with relatives. Not even the news about the Omicron variant being present here in the Philippines impacted them. Fortunately for Filipinos, Omicron cases in the country are very few and all of those were detected from passengers who arrived from overseas. As of this writing, the Omicron variant has not been detected in the local population.

Let me end this piece by asking you readers: What can you say about this latest development? Do you believe OCTA Research’s analysis about the holiday frenzy being the factor behind the slight rise of COVID-19 positivity? Do you personally know people who still remained unvaccinated to this day? Are you aware about Sputnik vaccines being more effective against the Omicron variant (read a related article by clicking here) and that Pfizer’s vaccines are less effective?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

+++++

Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

For more South Metro Manila community news and developments, come back here soon. Also say NO to fake news, NO to irresponsible journalism, NO to misinformation, NO to plagiarists, NO to reckless publishers and NO to sinister propaganda when it comes to news and developments. For South Metro Manila community developments, member engagements, commerce and other relevant updates, join the growing South Metro Manila Facebook group at https://www.facebook.com/groups/342183059992673

COVID-19 Crisis: Gamaleya Center’s preliminary study shows Sputnik vaccines are effective against Omicron variant

Have you been inoculated with the vaccine of Sputnik V or Sputnik Light before? In case you missed the news, the people behind the Russian vaccines made some profound announcements in relation to the Omicron variant which continues to infect a lot of people in many parts of the world (note: a 3rd Omicron case has just been confirmed here in the Philippines). Also revealed were comparisons with other brands of COVID-19 vaccines.

To put things in perspective, posted below is the first of two excerpts from the official press release published on the Sputnik Vaccine website. Some parts in boldface…

Moscow, December 17, 2021 – A preliminary laboratory study conducted by the Gamaleya Center has demonstrated that the Sputnik V vaccine and the one-shot Sputnik Light booster (based on human adenovirus serotype 26, the first component of Sputnik V) are effective against Omicron (B.1.1.529) variant of COVID, providing for better protection when compared to other vaccines.

Heterologous boosting with Sputnik Light is the solution to increase other vaccines’ efficacy, including against Omicron, and extend the booster protection period.

Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination and is a universal booster to other vaccines inducing stronger antibody and T-cell response.

Efficacy of mRNA vaccines has proven to be waning, demonstrated by a number of scientific publications. A Swedish study in The Lancet journal [4] has shown that Pfizer vaccine’s efficacy against Delta is falling to 47% after 4 months, to 29% after 6 months and to 23% after 7 months. The recent study in US among 65+ years olds demonstrated the decrease in mRNA vaccine effectiveness accelerating against Delta after month 4, reaching a low of approximately 20% in months 5 through 7 [5].

Recognizing the waning efficacy of mRNA vaccines, EU, UK, Greece, South Korea and other countries have recommended reducing the boosting period from 6 to 3 months.

Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light as well as heterologous boosting can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge.

Sputnik Light has already been registered in more than 20 countries as a standalone vaccine and a universal booster to other vaccines helping to increase their efficacy (including in Argentina, UAE, Bahrain, Philippines, and San Marino). Sputnik V has been authorized in 71 countries with total population of over 4 billion people.

Sputnik Light has already shown strong results used as a booster in mix & match trials in Argentina. A combination of Sputnik Light with vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino, conducted in 5 provinces (City and Province of Buenos Aires, as well as Córdoba, La Rioja and San Luis) has demonstrated that Sputnik Light induces stronger antibody and T-cell response as compared to homologous regimen (two shots of the same vaccine). Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on the 14th day after administering a second dose when compared to original homogenous (same vaccine as first and second dose) regimens of each of the vaccines.

Authors of a study in Argentina have noted that protection against coronavirus remains stable over at least 4 months following vaccination with the Russian Sputnik V vaccine as a consequence of antibody maturation, resulting in improved potency of antibodies to viral escape mutations. The study results were summarized in an article at https://www.medrxiv.org/content/10.1101/2021.08.22.21262186v1

Sputnik Light efficacy data:

  • Sputnik Light has been proven to be safe and highly effective by real-world vaccination data. In particular, data from the Ministry of Health of Buenos Aires (Argentina) has demonstrated standalone efficacy of Sputnik Light between 78.6-83.7% among the elderly (over 40,000 people of 60-79 years old), which is higher than that of many two-dose vaccines.
  • Findings by the Gamaleya Center based on data collected in Moscow have demonstrated Sputnik Light vaccine administered standalone has 70% efficacy against infection from the Delta variant of coronavirus during the first three months after vaccination. The vaccine is 75% effective among subjects under the age of 60. Sputnik V and Sputnik Light are based on a safe and effective human adenoviral vector platform and have not been associated with rare serious adverse events following vaccination, such as myocarditis or pericarditis.

Take note that this is not the first time that the group behind Sputnik V and Sputnik Light claimed their current vaccines are effective against the Omicron variant. Regardless, they went ahead developing a new and upcoming version of the Sputnik vaccine with Omicron in mind.

Going back to the above press release excerpt, the findings (conducted by other studies done by different research groups) exposed the weakness of mRNA vaccines particularly on efficacy against the Delta variant. If mRNA vaccines really cannot protect the vaccinated people from the Delta variant, how can they protect them from the much more contagious Omicron variant?

And now for the other details from the Sputnik Vaccine press release posted in the other excerpt below. Some parts are in bold face. Please read closely…

  • The Gamaleya Center’s recent preliminary laboratory study shows that Sputnik V demonstrates high virus neutralizing activity (VNA) against the Omicron (B.1.1.529) variant and is expected to provide strong defense against severe disease and hospitalization.
  • Sputnik V has demonstrated 3-7x less of a reduction in virus neutralizing activity against Omicron as compared to data from other vaccine producers: 11.8 times decrease of VNA for Sputnik V in contrast with 41 times decrease for Pfizer-BioNTech (according to the study led by scientists from Africa Health Research Institute published on Dec 7, 2021 [1]) and 49-84 times decrease for Moderna (according to the study published by research group from scientific institutes including Vaccine Research Center on Dec 15, 2021 [2]). So far, Sputnik V is showing the best virus neutralization results against Omicron in comparison with other vaccines.
  • The study was conducted using sera with a longer period after vaccination (more than 6 months after vaccination) as an indicator of Sputnik V’s long-lasing protection, in contrast with short studied periods for other vaccines producers (12-27 days for Pfizer-BioNTech and 28 days for Moderna).
  • Sputnik V elicits strong and long-lasting T-cell response, and as 80% of epitopes in the spike protein are not affected by the mutations in the Omicron variant, Sputnik V is expected to provide long-lasting protection against severe disease by Omicron. Sputnik V’s long-lasting T-cell immunity contributes to 80% efficacy against Delta on months 6-8 compared with efficacy of less than 29% demonstrated by certain mRNA vaccines after 6 months.
  • Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination. Virus neutralizing activity against Omicron 2-3 months after a Sputnik Light booster in this preliminary laboratory study is higher than VNA against the wild-type virus 6 months after Sputnik V vaccination. Based on these data the expected efficacy of Sputnik V with Sputnik Light booster against Omicron infection could be more than 80%, as Sputnik V showed efficacy of more than 80% against wild-type virus 6 month after vaccination.
  • 100% of individuals revaccinated with Sputnik Light as a booster developed neutralizing antibodies against Omicron and demonstrated their high level 2-3 months after the revaccination in contrast with only 25% of Pfizer booster recipients showing detectable level of neutralizing antibodies 3 month after vaccination (as demonstrated in the study published by research group from scientific institutes including Institute for Medical Virology (Frankfurt) on Dec 13, 2021 [3]).
  • Sputnik Light booster is expected to provide strong protection against infection, severe disease and hospitalization by Omicron. Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge. Sputnik Light is a universal booster to other vaccines, including Sputnik V. In Argentina, a combination of Sputnik Light with other vaccines has demonstrated its effectiveness as a universal booster inducing stronger antibody and T-cell response compared to a two-shots homologous regimen.
  • Sputnik V and Sputnik Light were developed on the basis of a safe and well-studied over 30 years technology and have not been associated with rare serious side effects as myocarditis or pericarditis.
    • The highest safety and efficacy of Sputnik V and Sputnik Light was demonstrated in more than 30 studies and real-world data publications from more than 10 countries.

Let me end this piece by asking you readers: What can you say about this latest announcement by the team behind the Sputnik vaccines? Do all the above details convince you to get a Sputnik vaccine as your first dose or as your booster shot? Has the Omicron variant infected people there in your local community?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

+++++

Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Millions of Sputnik V vaccine doses plus 5,000 Sputnik Light vaccine doses in the Philippines

Last week, a few million brand new doses of Sputnik V vaccines arrived here in the Philippines and at the same time, the single-dose Sputnik Light vaccine also arrived according to a Philippine News Agency (PNA) report.

You must be wondering what the differences between Sputnik V and Sputnik Light are. To understand things better, posted are excerpts about the two vaccines from SputnikVaccine.com for your reference. Some parts in boldface…

About Sputnik V

Sputnik V is the world’s first registered vaccine based on a well-studied human adenovirus vector platform. It has been approved for use in 71 countries with a total population of 4 billion people.

The vaccine is named after the first Soviet space satellite. The launch of Sputnik-1 in 1957 reinvigorated space research around the world, creating a so called “Sputnik moment” for the global community.

The vaccine’s efficacy is 97.6%, based on the analysis of data on the incidence of coronavirus among Russians vaccinated with both vaccine components between December 5, 2020 and March 31, 2021.

Phase 1 and 2 clinical trials for the vaccine were completed on August 1, 2020. The Phase 3 clinical trial results were published in Russia in the Lancet magazine on February 2, 2021. Phase 3 clinical trials of Sputnik V have also been successful in the UAE, India, Venezuela and Belarus.

The Sputnik V vaccine is based on a proven well-studied human adenovirus vector platform; these vectors cause the common cold and have plagued humanity for millennia.

Sputnik V was the first coronavirus vaccine to use a heterogeneous boosting approach based on 2 different vectors for 2 vaccine shots. This approach generates a more sustainable immunity compared to vaccines that use the same delivery mechanism for both shots.

The safety, efficacy and lack of long-term adverse effects of adenovirus vaccines have been proven in more than 250 clinical trials over two decades.

Sputnik V does not cause severe allergies.

A storage temperature of +2…+8 °C allows the vaccine to be stored in a regular refrigerator without the need to invest in additional cold chain infrastructure.

Sputnik V is effective against new strains of coronavirus, according to a study by the Gamaleya Research Institute for Epidemiology and Microbiology published in the leading international magazine Vaccines.

The vaccine produces protective neutralising antibody titres against new strains, including Alpha B.1.1.7 (first identified in the UK), Beta B.1.351 (first identified in South Africa), Gamma P.1 (first identified in Brazil), Delta B.1.617.2 and B.1.617.3 (first identified in India) and variants B.1.1.141 and B.1.1.317 with mutations in the receptor-binding domain (RBD) identified in Moscow.

About Sputnik Light

Sputnik Light is the first component (recombinant human adenovirus serotype number 26 (rAd26)) of Sputnik V – the world’s first registered vaccine against coronavirus.

The Sputnik Light vaccine, like Sputnik V, is based on a proven well-studied human adenovirus vector platform; these vectors cause the common cold and have peacefully coexisted with humanity for millenia.

Safety of Sputnik Light, as the first component of Sputnik V, was confirmed by real-world data from UAE, Bahrain, Argentina, Russia, Mexico, Serbia, San Marino, Philippines, Libya, Paraguay, Hungary, Azerbaijan and Belarus.

Sputnik Light, the first component of Sputnik V, is a safe and approved stand-alone one-shot vaccine. 80% proven efficacy against infection, higher than that of most two-shot vaccines.

Sputnik Light is also a leading booster shot for people previously infected with COVID-19 (and) for revaccinations after Sputnik V or other vaccines.

Sputnik Light as a stand-alone vaccine is highly effective against Delta and other mutations: 70% efficacy against infection by Delta, over 75% efficacy in the age group below 60. Efficacy against hospitalization and severe disease is even higher. Sputnik Light efficacy as a booster will be close to that of two shots of Sputnik V against Delta.

Sputnik Light has a long-lasting protection, which even increases over 4-6 months following the vaccination. Many other vaccines showed dramatic decrease in efficacy against Delta variant to below 50% within the same time period.

Were you about to absorb all the details in the above excerpts? Whatever you think of Sputnik V and Sputnik Light, I recommend you read their respective full articles on the official Sputnik Vaccine website.

And now we can proceed on the recent news about the two Russian vaccines and the Philippines. To put things in perspective, posted below is the excerpt from the PNA report. Some parts in boldface…

The Philippines plans to procure more of the one-shot Sputnik Light anti-coronavirus disease 2019 (Covid-19) vaccine after receiving its first batch, donated by Russia, on Friday.

A total of 5,000 doses of the Sputnik Light vaccine arrived at the Ninoy Aquino International Airport (NAIA) Terminal 2, along with the 2,805,000 doses (1,402,500 doses each of Components I and II) of Sputnik V shots, which were procured by the Philippine government.

National Task Force Against Covid-19 chief implementer, Secretary Carlito Galvez Jr., said negotiations are underway for the procurement of at least 10 million more doses of Sputnik Light.

“We are confident that these talks would yield positive results as we diversify our vaccine portfolio and scale up our vaccine throughput and achieve herd immunity by the first quarter of 2022,” Galvez said in an interview. “We are very happy that we will be renegotiating again for Sputnik Light.

He said the government would allocate the first batch of the one-shot Sputnik Light vaccine to the Bangsamoro Autonomous Region in Muslim Mindanao, which has the lowest vaccination rate among the 17 regions, with about 320,000 fully inoculated out of the 2.9 million target population.

“Ibigay muna natin sa mga hindi pa nakakakuha ng (Let’s give these to those who have yet to get) protection. I believe it is more useful na gamitin itong (to use these) as first dose so we can at least protect na agad ‘yung (right away the) first 5,000,” Galvez said.

He said the latest delivery of 2.8 million doses of Sputnik V completes the government’s procurement contract with the Russian Direct Investment Fund for the supply of 10 million doses.

“The completion of this contract is a testament to the robust relationship between our countries. Moreover, it demonstrates Russia’s strong commitment to helping provide greater vaccine accessibility to all nations, including the Philippines,” Galvez said. “We will be able to protect five million more Filipinos from the fatal effect of the Covid-19 virus and continue to bring down our active caseload and save more lives.”

Department of Health (DOH) Secretary Francisco Duque III said the Sputnik Light vaccine may be more effective as a booster shot.

“Mukhang maganda for booster iyong Sputnik Light. Mas mahaba daw ang (The Sputnik Light may be better used for booster shots. It gives longer) protection of about eight months beyond,” Duque said in another interview. “We’re going to have our vaccine expert panel review the documents.

Galvez echoed Duque’s statements, saying the Sputnik Light could boost the primary doses that are adenoviral vector-based vaccines, such as AstraZeneca and the similar single-dose Janssen.

“There are many scholars in Jordan saying the Sputnik Light is good. And also, this fits with our heterologous or mix and match of boosters,” he said.

The Food and Drug Administration amended the emergency use authorization of the following vaccine brands to include an additional shot – Pfizer, AstraZeneca, Sinovac, and Sputnik Light.

Let me end this piece by asking you readers: What can you say about this new development? If you have been vaccinated with Sputnik V, how long has it been since your last shot? If you are fully vaccinated already, regardless of vaccine brands, would you be willing to accept a Sputnik vaccine as your booster shot?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

+++++

Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/