COVID-19 Crisis: Clinical trials in Russia and Azerbaijan demonstrate the safety and immunogenicity of AstraZeneca vaccine mixed with Sputnik Light

Are the local authorities in your place organizing COVID-19 vaccination programs with supplies of Sputnik V or the single-dose Sputnik Light vaccine in supply?  For the sake of protecting people from the coronavirus and its variants, local and national authorities should seriously consider acquiring more doses of Sputnik vaccines from Gamaleya as two new studies – one in Russia and the other in Azerbaijan – demonstrated the safety and immunogenicity of AstraZeneca mixed with Sputnik Light as announced recently at SputnikVaccine.com. This is apart from the confirmed findings that Sputnik vaccines effective against the highly infectious Omicron variant (for references, click here, here and here).

To put things in perspective, posted below is the excerpt from the official press release published at SputnikVaccine.com. Some parts in boldface…

The Russian Direct Investment Fund (RDIF, Russia’s sovereign wealth fund), R-Pharm group and AstraZeneca announce interim results of phase II clinical trials to evaluate the safety and immunogenicity of the combined use of AstraZeneca’s vaccine and the first component of the Sputnik V coronavirus vaccine (Sputnik Light).

According to the interim results of the trials, involving 100 volunteers in Russia and 100 volunteers in Azerbaijan, the vaccines combination demonstrated an acceptable safety profile, which is consistent with the results of previous AstraZeneca vaccine, Sputnik V and Sputnik Light vaccines clinical trials.

Volunteers were being monitored for 57 days after the first dose. Monitoring results demonstrated a good safety profile of the combination. No serious adverse events related to vaccination were registered.

The research conducted by RDIF, the Gamaleya Center, AstraZeneca, and R-Pharm is the first study in the world to evaluate the combined use of components of different adenovirus vaccines to prevent coronavirus infection. In December 2021, the World Health Organization (WHO) recommended a similar approach, also known as heterologous prime booster vaccination.[i] The WHO estimates that interchangeability of different drugs will allow greater flexibility in vaccination programs, increase vaccine efficacy and affordability.

A joint phase II clinical trial to evaluate the safety and immunogenicity of a combination of AstraZeneca’s vaccine and the first component of the Sputnik V vaccine is being conducted under the memorandum signed in December 2020 by the Russian Direct Investment Fund, the Gamaleya Center, AstraZeneca and R-Pharm. The study takes place in Azerbaijan, Russia and the United Arab Emirates. Volunteers receive intramuscular injections of the AstraZeneca vaccine and the Ad26-S component of the Sputnik V vaccine in different sequences at 28-day intervals.

Kirill Dmitriev, CEO of the Russian Direct Investment Fund (RDIF): Preliminary data from the trial to test Sputnik Light and AstraZeneca vaccines combination support the “mix and match” approach to revaccination. With new dangerous variants of concern emerging, this approach could provide safe, effective and long-term protection.

Vasily Ignatiev, CEO of the R-Pharm Group JSC: Current safety data adds to the data on the high immunogenicity profile of the vaccine combination that has been announced earlier. We are one step closer to completing the studies. The results are being processed.

In relation to the above press release, you might want to remember what specific brands of COVID-19 vaccines did you get injected with. If you got Sputnik V for your first two doses and AstraZeneca as your booster shot, then you should be protected. As for Sputnik Light, there’s not enough supplies of it here in the Philippines. Sputnik Light and AstraZeneca make an effective and safe combination as far as COVID-19 vaccine mix-and-match goes.

Let me end this piece by asking you readers: What do you think about this recent news development? If you have been fully vaccinated but have yet to get boosted, does this latest development convince you to search for a Sputnik vaccine or AstraZeneca as your booster shot? Have you recently checked with the local vaccination organizers if they have sufficient supplies of both AstraZeneca and Sputnik vaccines? Are you aware that mRNA vaccines are flawed and the protection they provide fade away quickly?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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