Tag: Sinopharm

COVID-19 Crisis: Gamaleya Center’s preliminary study shows Sputnik vaccines are effective against Omicron variant

COVID-19 Crisis: Gamaleya Center’s preliminary study shows Sputnik vaccines are effective against Omicron variant

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Have you been inoculated with the vaccine of Sputnik V or Sputnik Light before? In case you missed the news, the people behind the Russian vaccines made some profound announcements in relation to the Omicron variant which continues to infect a lot of people in many parts of the world (note: a 3rd Omicron case has just been confirmed here in the Philippines). Also revealed were comparisons with other brands of COVID-19 vaccines.

To put things in perspective, posted below is the first of two excerpts from the official press release published on the Sputnik Vaccine website. Some parts in boldface…

Moscow, December 17, 2021 – A preliminary laboratory study conducted by the Gamaleya Center has demonstrated that the Sputnik V vaccine and the one-shot Sputnik Light booster (based on human adenovirus serotype 26, the first component of Sputnik V) are effective against Omicron (B.1.1.529) variant of COVID, providing for better protection when compared to other vaccines.

Heterologous boosting with Sputnik Light is the solution to increase other vaccines’ efficacy, including against Omicron, and extend the booster protection period.

Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination and is a universal booster to other vaccines inducing stronger antibody and T-cell response.

Efficacy of mRNA vaccines has proven to be waning, demonstrated by a number of scientific publications. A Swedish study in The Lancet journal [4] has shown that Pfizer vaccine’s efficacy against Delta is falling to 47% after 4 months, to 29% after 6 months and to 23% after 7 months. The recent study in US among 65+ years olds demonstrated the decrease in mRNA vaccine effectiveness accelerating against Delta after month 4, reaching a low of approximately 20% in months 5 through 7 [5].

Recognizing the waning efficacy of mRNA vaccines, EU, UK, Greece, South Korea and other countries have recommended reducing the boosting period from 6 to 3 months.

Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light as well as heterologous boosting can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge.

Sputnik Light has already been registered in more than 20 countries as a standalone vaccine and a universal booster to other vaccines helping to increase their efficacy (including in Argentina, UAE, Bahrain, Philippines, and San Marino). Sputnik V has been authorized in 71 countries with total population of over 4 billion people.

Sputnik Light has already shown strong results used as a booster in mix & match trials in Argentina. A combination of Sputnik Light with vaccines produced by AstraZeneca, Sinopharm, Moderna and Cansino, conducted in 5 provinces (City and Province of Buenos Aires, as well as Córdoba, La Rioja and San Luis) has demonstrated that Sputnik Light induces stronger antibody and T-cell response as compared to homologous regimen (two shots of the same vaccine). Each “vaccine cocktail” combination with Sputnik Light provided higher antibody titer on the 14th day after administering a second dose when compared to original homogenous (same vaccine as first and second dose) regimens of each of the vaccines.

Authors of a study in Argentina have noted that protection against coronavirus remains stable over at least 4 months following vaccination with the Russian Sputnik V vaccine as a consequence of antibody maturation, resulting in improved potency of antibodies to viral escape mutations. The study results were summarized in an article at https://www.medrxiv.org/content/10.1101/2021.08.22.21262186v1

Sputnik Light efficacy data:

  • Sputnik Light has been proven to be safe and highly effective by real-world vaccination data. In particular, data from the Ministry of Health of Buenos Aires (Argentina) has demonstrated standalone efficacy of Sputnik Light between 78.6-83.7% among the elderly (over 40,000 people of 60-79 years old), which is higher than that of many two-dose vaccines.
  • Findings by the Gamaleya Center based on data collected in Moscow have demonstrated Sputnik Light vaccine administered standalone has 70% efficacy against infection from the Delta variant of coronavirus during the first three months after vaccination. The vaccine is 75% effective among subjects under the age of 60. Sputnik V and Sputnik Light are based on a safe and effective human adenoviral vector platform and have not been associated with rare serious adverse events following vaccination, such as myocarditis or pericarditis.

Take note that this is not the first time that the group behind Sputnik V and Sputnik Light claimed their current vaccines are effective against the Omicron variant. Regardless, they went ahead developing a new and upcoming version of the Sputnik vaccine with Omicron in mind.

Going back to the above press release excerpt, the findings (conducted by other studies done by different research groups) exposed the weakness of mRNA vaccines particularly on efficacy against the Delta variant. If mRNA vaccines really cannot protect the vaccinated people from the Delta variant, how can they protect them from the much more contagious Omicron variant?

And now for the other details from the Sputnik Vaccine press release posted in the other excerpt below. Some parts are in bold face. Please read closely…

  • The Gamaleya Center’s recent preliminary laboratory study shows that Sputnik V demonstrates high virus neutralizing activity (VNA) against the Omicron (B.1.1.529) variant and is expected to provide strong defense against severe disease and hospitalization.
  • Sputnik V has demonstrated 3-7x less of a reduction in virus neutralizing activity against Omicron as compared to data from other vaccine producers: 11.8 times decrease of VNA for Sputnik V in contrast with 41 times decrease for Pfizer-BioNTech (according to the study led by scientists from Africa Health Research Institute published on Dec 7, 2021 [1]) and 49-84 times decrease for Moderna (according to the study published by research group from scientific institutes including Vaccine Research Center on Dec 15, 2021 [2]). So far, Sputnik V is showing the best virus neutralization results against Omicron in comparison with other vaccines.
  • The study was conducted using sera with a longer period after vaccination (more than 6 months after vaccination) as an indicator of Sputnik V’s long-lasing protection, in contrast with short studied periods for other vaccines producers (12-27 days for Pfizer-BioNTech and 28 days for Moderna).
  • Sputnik V elicits strong and long-lasting T-cell response, and as 80% of epitopes in the spike protein are not affected by the mutations in the Omicron variant, Sputnik V is expected to provide long-lasting protection against severe disease by Omicron. Sputnik V’s long-lasting T-cell immunity contributes to 80% efficacy against Delta on months 6-8 compared with efficacy of less than 29% demonstrated by certain mRNA vaccines after 6 months.
  • Sputnik Light as a booster significantly increases virus neutralizing activity against Omicron based on sera 2-3 months after revaccination. Virus neutralizing activity against Omicron 2-3 months after a Sputnik Light booster in this preliminary laboratory study is higher than VNA against the wild-type virus 6 months after Sputnik V vaccination. Based on these data the expected efficacy of Sputnik V with Sputnik Light booster against Omicron infection could be more than 80%, as Sputnik V showed efficacy of more than 80% against wild-type virus 6 month after vaccination.
  • 100% of individuals revaccinated with Sputnik Light as a booster developed neutralizing antibodies against Omicron and demonstrated their high level 2-3 months after the revaccination in contrast with only 25% of Pfizer booster recipients showing detectable level of neutralizing antibodies 3 month after vaccination (as demonstrated in the study published by research group from scientific institutes including Institute for Medical Virology (Frankfurt) on Dec 13, 2021 [3]).
  • Sputnik Light booster is expected to provide strong protection against infection, severe disease and hospitalization by Omicron. Sputnik Light booster is recommended to strengthen efficacy of vaccines against Omicron. Boosting by Sputnik Light can strengthen and lengthen the quickly waning efficacy of many vaccines in light of combined Delta and Omicron challenge. Sputnik Light is a universal booster to other vaccines, including Sputnik V. In Argentina, a combination of Sputnik Light with other vaccines has demonstrated its effectiveness as a universal booster inducing stronger antibody and T-cell response compared to a two-shots homologous regimen.
  • Sputnik V and Sputnik Light were developed on the basis of a safe and well-studied over 30 years technology and have not been associated with rare serious side effects as myocarditis or pericarditis.
    • The highest safety and efficacy of Sputnik V and Sputnik Light was demonstrated in more than 30 studies and real-world data publications from more than 10 countries.

Let me end this piece by asking you readers: What can you say about this latest announcement by the team behind the Sputnik vaccines? Do all the above details convince you to get a Sputnik vaccine as your first dose or as your booster shot? Has the Omicron variant infected people there in your local community?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

COVID-19 Crisis: Sputnik vaccines versus Omicron

COVID-19 Crisis: Sputnik vaccines versus Omicron

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Have you been injected with a Sputnik vaccine? Are all the rabid news reports about the Omicron variant making you feel uncomfortable? Here is something that you should focus on temporarily – an official statement was recently released claiming that Sputnik V and Sputnik Light vaccines are effective against all variants of SRAC-Cov-2 and they will prove effective in neutralizing the Omicron variant. As if that was not enough, a new version of the Sputnik vaccine is already being developed with Omicron in mind.

To put things in perspective, posted below is an excerpt from the statement published by SputnikVaccine.com. Some parts in boldface…

The Russian Sputnik V and Sputnik Light vaccines have proven to be highly effective against all variants of SARC-Cov-2 known to date. This has been demonstrated by an article published in Vaccines medical journal and international real-world data from numerous countries:

A recent study in Hungary demonstrated Sputnik V vaccine had the highest (98%) efficacy in preventing COVID-related mortality and 85.7% efficacy against coronavirus infection among five vaccines (Sputnik V, Moderna, Pfizer, AstraZeneca and Sinopharm) used in the country between January-June 2021. Based on this data, the share of deaths from COVID in the unvaccinated population was 130 times higher than among those vaccinated with Sputnik V in the same period.

According to data from San Marino, Sputnik V is 80% effective against coronavirus infection from 6th to 8th months after administering the second dose, which is much higher than published efficacy of mRNA vaccines of less than 30% after 6 months.

The Sputnik vaccine’s efficacy is based on the heterogeneous boosting approach using two different vectors for two shots, pioneered by the Gamaleya Institute, and a proven adenoviral vector platform, which triggers a broader immune response as compared to mRNA vaccines.

The Gamaleya Institute believes both Sputnik V and Sputnik Light will neutralize the latest Omicron variant and has started the necessary studies.

Nonetheless the Gamaleya Institute, based on existing protocols of immediately developing vaccine versions for variants of concern, has already begun developing the new version of Sputnik vaccine adapted to Omicron. In an unlikely case such modification is needed, the new Sputnik Omicron version can be ready for mass-scale production in 45 days. Several hundred million Sputnik Omicron boosters can be provided to international markets already by Feb 20, 2022 with over 3 billion doses available in 2022.

That was a pretty bold statement there. Sputnik vaccines’ efficacies (preventing COVID-19  mortality and going against coronavirus infections) was compared with four other established brands of COVID-19 vaccines.

With regards to Omicron, there was confidence expressed that the two existing Sputnik vaccines will neutralize the new variant. That sounds great but I would love to see first real test results to prove that. Regardless, Gamaleya proceeded already to develop a newer version of Sputnik vaccine with Omicron in mind and they seem confident they can mass produce it and start releasing it in early 2022. As seen in the above statement, the mass production and release of a Sputnik Omicron vaccine would commence in the unlikely case they need to modify the Sputnik vaccine.

If the current Sputnik vaccines prove to be capable of neutralizing the Omicron variant, then no such production-release scheme of a modified vaccine will be needed. Gamaleya will then have to keep mass producing and sending out doses of Sputnik V and Sputnik Light worldwide. Already millions of doses of Sputnik V have arrived here in the Philippines and the national government plans to procure more of the single-dose Sputnik Light vaccine.

For added insight, watch these related news videos below…

Let me end this piece by asking you readers: What can you say about this official statement about Sputnik vaccines and the Omicron variant? If you were fully vaccinated with the Sputnik V vaccine, how long has it been since your 2nd dose? Is your local government already releasing booster shots? Are you eager to find out if your local government will use Sputnik vaccine as your booster shot? Do you believe that Gamaleya’s statement that the two current Sputnik vaccines will really neutralize the Omicron variant?

You may answer in the comments below. If you prefer to answer privately, you may do so by sending me a direct message online.

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Thank you for reading. If you find this article engaging, please click the like button below and also please consider sharing this article to others. If you are looking for a copywriter to create content for your special project or business, check out my services and my portfolio. Feel free to contact me with a private message. Also please feel free to visit my Facebook page Author Carlo Carrasco and follow me on Twitter at  @HavenorFantasy as well as on Tumblr at https://carlocarrasco.tumblr.com/

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